UNRAVELLING THE ETHNOMEDICINAL SIGNIFICANCE, PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL OF COPTIS TEETA WALL
DOI:
https://doi.org/10.66302/api.vol.1.issue.01.02Keywords:
Coptis teeta, secondary metabolites, traditional medicine, BerberineAbstract
The plant kingdom, one of the main life-supporting systems, was a gift from nature to the planet. The distribution of medicinal plants varies depending on the geographical zones around the world. Certain medicinal plants have huge potential for distribution, while others such as Coptis teeta, are gradually losing their natural habitat and facing extinction. The non-timber forest plant Coptis teeta is primarily found in northwest Yunnan (China), Bhutan, and northeast India, particularly in Arunachal Pradesh’s temperate zones. The rhizome of this plant is well-known in Chinese and North East Indian traditional medicine for preventing and treating a variety of human illnesses. According to numerous reports and studies, Coptis teeta includes a number of alkaloids, such as berberine, palmatine, jatrorrhizine, coptisine, columbamine, and epiberberine, as well as secondary metabolites, lignans, phenylpropanoids, flavonoids, phenolic acids, saccharides, and steroids. In order to improve drug quality assessment and management, numerous high-content components in Coptis extracts will be studied qualitatively and quantitatively. Due to its diverse nature and extensive range of pharmacological actions, Coptis teeta cultivation and multiplication should be done with care and patience. This review’s goals are to summarise the present level of knowledge regarding the Coptis teeta plant, outline its pharmacological functions, and identify the causes of its extinction.
References
Ates, D., & Turgay, Ö. (2003). Antimicrobial activities of
various medicinal and commercial plant extracts. Turkish
Journal of Biology, 27(3), 157–162.
https://journals.tubitak.gov.tr/biology/vol27/iss3/6/.
Bajpay, A., Nainwal, R., & Singh, D. (2019). Coptis teeta: A
potential endemic and endangered medicinal plant of
Eastern Himalayas. Journal of Pharmacognosy and
Phytochemistry, 8(4), 245–248.
Bhattee, S. S., & Beniwal, B. S. (1988). Coptis teeta wall. -
An important and valuable medicinal plant of Arunachal
Pradesh and its cultivation. Indian Forester, 251–260.
https://doi.org/10.36808/if/1988/v114i5/9200.
Boniface, P. K., Verma, S., Shukla, A., Cheema, H. S.,
Srivastava, S. K., Khan, F., Darokar, M. P., & Pal, A.
(2015). Bioactivity-guided isolation of antiplasmodial
constituents from conyza sumatrensis (Retz.) E.H.
Walker. Parasitology International, 64(1), 118–123.
https://doi.org/10.1016/j.parint.2014.10.010.
Chander Semwal, B., Gupta, J., Singh, S., Kumar, Y., & Giri,
M. (2009). Antihyperglycemic activity of root of
Berberis aristata D.C. in alloxan-induced diabetic rats.
International Journal of Green Pharmacy (IJGP), 3(3).
https://doi.org/10.22377/ijgp.v3i3.97.
Cheema, H. S., Prakash, O., Pal, A., Khan, F., Bawankule, D.
U., & Darokar, M. P. (2014). Glabridin induces oxidative
stress mediated apoptosis like cell death of malaria
parasite plasmodium falciparum. Parasitology
International, 63(2), 349–358.
https://doi.org/10.1016/j.parint.2013.12.005.
Cheema, H. S., & Singh, M. P. (2021). The use of medicinal
plants in digestive system related disorders- A systematic
review. Journal of Ayurvedic and Herbal Medicine, 7(3),
182–187. https://doi.org/10.31254/jahm.2021.7303.
Chelleng, N., Sonia, H., & Tamuly, C. (2024). Coptis teeta
wall.: A comprehensive overview of its traditional uses,
pharmacological uses, phytochemicals and conservation.
Future Integrative Medicine, 3(1), 21–34.
https://doi.org/10.14218/fim.2023.00082.
Dalli, A. K., Saha, G., & Chakraborty, U. (2007).
Characterization of antimicrobial compounds from a
common fern, Pteris biaurita. PubMed, 45(3), 285–290.
De Pasquale, A. (1984). Pharmacognosy: The oldest modern
science. Journal of Ethnopharmacology, 11(1), 1–16.
https://doi.org/10.1016/0378-8741(84)90092-8.
Domitroviæ, R., Jakovac, H., & Blagojeviæ, G. (2011).
Hepatoprotective activity of berberine is mediated by
inhibition of TNF-á, COX-2, and iNOS expression in
CCl4-intoxicated mice. Toxicology, 280(1–2), 33–43.
https://doi.org/10.1016/j.tox.2010.11.005.
Eaker, E. Y., & Sninsky, C. A. (1989). Effect of berberine on
myoelectric activity and transit of the small intestine in
rats. Gastroenterology, 96(6), 1506–1513.
https://doi.org/10.1016/0016-5085(89)90519-2.
Gazit, A., App, H., McMahon, G., Chen, J., Levitzki, A., &
Bohmer, F. D. (1996). Tyrphostins. 5. Potent inhibitors of
platelet-derived growth factor receptor tyrosine kinase:
Structure-activity relationships in quinoxalines,
quinolines, and Indole Tyrphostins. Journal of Medicinal
Chemistry, 39(11), 2170–2177.
https://doi.org/10.1021/jm950727b.
Goswami, A. K., Sharma, H. K., Gogoi, N., Kashyap, A., &
Gogoi, B. (2022). In vitro evaluation and molecular
dynamics, DFT guided investigation
of antimalarial activity of ethnomedicinally used coptis
teeta wall. Combinatorial Chemistry & High Throughput
Screening, 25(2), 292–306.
https://doi.org/10.2174/1386207324666210118095503.
Hsieh, P.-C., Mau, J.-L., & Huang, S.-H. (2001).
Antimicrobial effect of various combinations of plant
extracts. Food Microbiology, 18(1), 35–43.
https://doi.org/10.1006/fmic.2000.0376.
Hui, K. K., Jun, L. Y., Chan, W. F. A., & Tse, E. (1991).
Interaction of berberine with human platelet á2
adrenoceptors. Life Sciences, 49(4), 315–324.
https://doi.org/10.1016/0024-3205(91)90019-8.
Ivanovska, N., & Philipov, S. (1996). Study on the
anti-inflammatory action of Berberis vulgaris root
extract, alkaloid fractions and pure alkaloids.
International Journal of Immunopharmacology, 18(10),
553–561.
https://doi.org/10.1016/s0192-0561(96)00047-1.
Jeong, J. B., Hong, S. C., Jeong, H. J., & Koo, J. S. (2011).
Anti-inflammatory effect of 2-methoxy-4-vinylphenol
via the suppression of NF-êB and MAPK activation, and
acetylation of histone H3. Archives of Pharmacal
Research, 34(12), 2109–2116.
https://doi.org/10.1007/s12272-011-1214-9.
Jeong, J. B., & Jeong, H. J. (2010).
2-Methoxy-4-vinylphenol can induce cell cycle arrest by
blocking the hyper-phosphorylation of retinoblastoma
protein in benzo[a]pyrene-treated NIH3T3 cells.
Biochemical and Biophysical Research
Communications, 400(4), 752–757.
https://doi.org/10.1016/j.bbrc.2010.08.142.
Jin, Y., Liu, S., Ma, Q., Xiao, D., & Chen, L. (2017).
Berberine enhances the AMPK activation and autophagy
and mitigates high glucose-induced apoptosis of mouse
podocytes. European Journal of Pharmacology, 794,
106–114. https://doi.org/10.1016/j.ejphar.2016.11.037.
Kalani, K., Yadav, D., Singh, A., Khan, F., Godbole, M. M.,
& Srivastava, S. K. (2014). QSAR guided semi-synthesis
and in-vitro validation of anticancer activity in ursolic
acid derivatives. Current Topics in Medicinal Chemistry,
14(8), 1005–1013.
https://doi.org/10.2174/1568026614666140324121606.
Kaneda, Y., Tanaka, T., & Saw, T. (1990). Effects of
berberine, a plant alkaloid, on the growth of anaerobic
protozoa in axenic culture. PubMed, 15(6), 417–423.
Khare, S., Gupta, M., Cheema, H. S., Maurya, A. K., Rout,
P., Darokar, M. P., & Pal, A. (2018). Rosa damascena
restrains Plasmodium falciparum progression in vitro
and impedes malaria pathogenesis in murine model.
Biomedicine & Pharmacotherapy, 97, 1654–1662.
https://doi.org/10.1016/j.biopha.2017.11.130.
Lao-ong, T., Chatuphonprasert, W., Nemoto, N., &
Jarukamjorn, K. (2012). Alteration of hepatic glutathione
peroxidase and superoxide dismutase expression in
streptozotocin-induced diabetic mice by berberine.
Pharmaceutical Biology, 50(8), 1007–1012.
https://doi.org/10.3109/13880209.2012.655377.
Latif, A., Razique, A., Sukulb Asadullah, R. R., & Zuberi, R.
H. (2008). Phytochemical and physico-chemical study of
coptis teeta wall.: An effective drug of choice in ocular
ailments. European Journal of Integrative Medicine, 1,
22–23. https://doi.org/10.1016/j.eujim.2008.08.128.
Li, J.-Y., Wang, X.-B., Luo, J.-G., & Kong, L.-Y. (2015).
Seasonal variation of alkaloid contents and
anti-inflammatory activity of rhizoma coptidis based on
fingerprints combined with chemometrics methods.
Journal of Chromatographic Science, 53(7), 1131–1139.
https://doi.org/10.1093/chromsci/bmu175.
Liu, Da, Meng, X., Wu, D., Qiu, Z., & Luo, H. (2019). A
natural isoquinoline alkaloid with antitumor activity:
Studies of the biological activities of Berberine.
Frontiers in Pharmacology, 10.
https://doi.org/10.3389/fphar.2019.00009.
Liu, J.-C., Chan, P., Chen, Y.-J., Tomlinson, B., Hong, S.-F.,
& Cheng, J.-T. (1999). The antihypertensive effect of the
berberine derivative 6-Protoberberine in spontaneously
hypertensive rats. Pharmacology, 59(6), 283–289.
https://doi.org/10.1159/000028331.
Liu, W., Liu, P., Tao, S., Deng, Y., Li, X., Lan, T., Zhang, X.,
Guo, F., Huang, W., Chen, F., Huang, H., & Zhou, S.-F.
(2008). Berberine inhibits aldose reductase and oxidative
stress in rat mesangial cells cultured under high glucose.
Archives of Biochemistry and Biophysics, 475(2),
128–134. https://doi.org/10.1016/j.abb.2008.04.022.
Lone , T., Rahul, M., & Lone, R. (2014). In vitro
Anti-Oxidant Studies by Using Different Methods and
Evaluation of Anti-Microbial Potential of Coptis teeta.
Global Journal of Biotechnology and Biochemistry, 9(4),
99–104. https://doi.org/DOI:
10.5829/idosi.gjbb.2014.9.4.91138.
Maung Tin-Wa. (2010, August 23). US20110086872A1 -
berberine as a selective lung cancer agent and other
compositions and methods- google patents. Google.Com.
https://patents.google.com/patent/US20110086872A1/e
n.
Mehrzadi, S., Fatemi, I., Esmaeilizadeh, M., Ghaznavi, H.,
Kalantar, H., & Goudarzi, M. (2018). Hepatoprotective
effect of berberine against methotrexate induced liver
toxicity in rats. Biomedicine & Pharmacotherapy, 97,
233–239. https://doi.org/10.1016/j.biopha.2017.10.113.
Mohanty, S., Srivastava, P., Maurya, A. K., Cheema, H. S.,
Shanker, K., Dhawan, S., Darokar, M. P., & Bawankule,
D. U. (2013). Antimalarial and safety evaluation of
Pluchea lanceolata (DC.) Oliv. & Hiern: In-vitro and
in-vivo study. Journal of Ethnopharmacology, 149(3),
797–802. https://doi.org/10.1016/j.jep.2013.08.003.
Mukherjee, D. (2019). Coptis teeta: Conservation and
cultivation practice - a rare medicinal plant on earth.
Current Investigations in Agriculture and Current
Research, 6(4).
https://doi.org/10.32474/ciacr.2019.06.000244.
Payum, T. (2017). Distribution, ethnobotany,
pharmacognosy and phytoconstituents of Coptis Teeta
Wall.: A highly valued and threatened medicinal plant of
Eastern Himalayas. Pharmacognosy Journal, 9(6s),
s28–s34. https://doi.org/10.5530/pj.2017.6s.154.
Pourmorad, F., Hosseinimehr, S. J., & Shahabimajd, N.
(2006). Antioxidant activity, phenol and flavonoid
contents of some selected Iranian medicinal plants.
African Journal of Biotechnology, 5(11), 1142–1145.
https://doi.org/10.5897/AJB06.168.
Preethi, R., Devanathan, V., & Loganathan, M. (2010).
Antimicrobial and antioxidant efficacy of some
medicinal plants against food borne pathogens. Advances
in Biological Research, 4(2), 122–125.
https://www.idosi.org/abr/4(2)/7.pdf.
Saxena, A., Yadav, D., Mohanty, S., Cheema, H. S., Gupta,
M. M., Darokar, M. P., & Bawankule, D. U. (2016).
Diarylheptanoids rich fraction of alnus nepalensis
attenuates malaria pathogenesis: in-vitro and in-vivo
study. Phytotherapy Research, 30(6), 940–948.
https://doi.org/10.1002/ptr.5596.
Shankar, D., & Rawat, R. D. (2013). Medicinal plants of
Arunachal Pradesh. International Book Distributors,
Booksellers and Publishers.
Shao, J., Zeng, D., Tian, S., Liu, G., & Fu, J. (2020).
Identification of the natural product berberine as an
antiviral drug. AMB Express, 10(1).
https://doi.org/10.1186/s13568-020-01088-2.
Singh, D. K., Cheema, H. S., Saxena, A., Jyotshana, Singh,
S., Darokar, M. P., Bawankule, D. U., Shanker, K., &
Luqman, S. (2017). Fraxetin and ethyl acetate extract
from lawsonia inermis L. ameliorate oxidative stress in P.
Berghei infected mice by augmenting antioxidant
defence system. Phytomedicine, 36, 262–272.
https://doi.org/10.1016/j.phymed.2017.09.012.
Sujatha, S., Anand, S., Sangeetha, K. N., Shilpa, K.,
Lakshmi, J., Balakrishnan, A., & Lakshmi, B. S. (2010).
Biological evaluation of (3â)-STIGMAST-5-EN-3-OL as
potent anti-diabetic agent in regulating glucose
transport using in vitro model. International Journal of
Diabetes Mellitus, 2(2), 101–109.
https://doi.org/10.1016/j.ijdm.2009.12.013.
Sun, Y., Xun, K., Wang, Y., & Chen, X. (2009). A systematic
review of the anticancer properties of berberine, a natural
product from Chinese herbs. Anti-Cancer Drugs, 20(9),
757–769.
https://doi.org/10.1097/cad.0b013e328330d95b.
Tan, Y., Tang, Q., Hu, B., & Xiang, J. (2007). Antioxidant
properties of berberine on cultured rabbit corpus
cavernosum smooth muscle cells injured by hydrogen
peroxide. Acta Pharmacologica Sinica, 28(12),
1914–1918.
https://doi.org/10.1111/j.1745-7254.2007.00705.x.
Teklemichael, A. A., Mizukami, S., Toume, K.,
Mosaddeque, F., Kamel, M. G., Kaneko, O., Komatsu,
K., Karbwang, J., Huy, N. T., & Hirayama, K. (2020).
Anti-malarial activity of traditional Kampo medicine
Coptis rhizome extract and its major active compounds.
Malaria Journal, 19(1).
https://doi.org/10.1186/s12936-020-03273-x.
Upadhyay, H. C., Sisodia, B. S., Cheema, H. S., Agrawal, J.,
Pal, A., Darokar, M. P., & Srivastava, S. K. (2013). Novel
antiplasmodial agents from Christia vespertilionis.
Natural Product Communications, 8(11), 1591–1594.
https://pubmed.ncbi.nlm.nih.gov/24427949/.
Wagner, H. (2005). Natural products chemistry and
phytomedicine in the 21st century: New developments
and challenges. Pure and Applied Chemistry, 77(1), 1–6.
https://doi.org/10.1351/pac200577010001.
Wang, Y., Campbell, T., Perry, B., Beaurepaire, C., & Qin,
L. (2011). Hypoglycemic and insulin-sensitizing effects
of berberine in high-fat diet- and streptozotocin-induced
diabetic rats. Metabolism, 60(2), 298–305.
https://doi.org/10.1016/j.metabol.2010.02.005.
Warowicka, A., Nawrot, R., & GoŸdzicka-Józefiak, A.
(2020). Antiviral activity of berberine. Archives of
Virology, 165(9), 1935–1945.
https://doi.org/10.1007/s00705-020-04706-3.
Xu, X., He, Y., & Liu, J. (2025). Berberine: A multifaceted
agent for lung cancer treatment-from molecular insight to
clinical applications. Gene, 934, 149021.
https://doi.org/10.1016/j.gene.2024.149021.
Xu, Z., Feng, W., Shen, Q., Yu, N.-N., Yu, K., Wang, S.,
Chen, Z., Shioda, S., & Guo, Y. (2017). Rhizoma
Coptidis and berberine as a natural drug to combat aging
and aging-related diseases via anti-oxidation and AMPK
activation. Aging and Disease, 8(6), 760–760.
https://doi.org/10.14336/ad.2016.0620.
Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in
patients with type 2 diabetes mellitus. Metabolism, 57(5),
712–717.
Yu, H.-H., Kim, K.-J., Cha, J.-D., Kim, H. J., Lee, Y. H.,
Choi, N.-Y., & You, Y.-O. (2005). Antimicrobial activity
of berberine alone and in combination with ampicillin or
oxacillin against methicillin-resistant staphylococcus
aureus. Journal of Medicinal Food, 8(4), 454–461.
https://doi.org/10.1089/jmf.2005.8.454.
Zhang, D., Arunachalam, K., Wang, Y., Zhang, Y., Yang, J.,
Hein, P. P., Mon, A. M., Li, J., Inta, A., & Yang, X.
(2021). Evaluation on Antidiabetic Properties of
Medicinal Plants from Myanmar. The Scientific World
Journal, 2021, 1–10.
https://doi.org/10.1155/2021/1424675.
Zhao, X., Zhang, J., Tong, N., Chen, Y., & Luo, Y. (2012).
Protective effects of berberine on doxorubicin-induced
hepatotoxicity in mice. Biological and Pharmaceutical
Bulletin, 35(5), 796–800.
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